Early insulin therapy Coordination Council

[Early insulin therapy in type 2 diabetes?].

Type 2 diabetes is characterized by progressive decline in pancreatic beta cell function and persistent insulin resistance. Decreased beta cell mass and amyloid deposits in the islet are the pathological hallmark of the disease. Preserved beta cell function is the most important determinant of glucose disposal, even after adjustment for insulin sensitivity, which might modulate beta cell functi...

Early insulin therapy in very-low-birth-weight infants.

BACKGROUND Studies involving adults and children being treated in intensive care units indicate that insulin therapy and glucose control may influence survival. Hyperglycemia in very-low-birth-weight infants is also associated with morbidity and mortality. This international randomized, controlled trial aimed to determine whether early insulin replacement reduced hyperglycemia and affected outc...

Insulin Therapy with Personal Insulin Pumps and Early Angiopathy in Children with Type 1 Diabetes Mellitus

OBJECTIVE Assessment of the effect of a treatment method change from multiple daily insulin injection (MDI) to continuous subcutaneous insulin infusion (CSII) on the development of early angiopathy in children with T1DM with or without retinopathy. METHODS The study pump group involved 32 diabetic children aged 14.8, with the initial HbA1c level of 8.3%, previously treated by MDI. The patient...

Early Work on Insulin.

Insulin Potentiation Therapy

Insulin potentiation therapy (IPT) is an unproven adjunct to cancer chemotherapy that uses insulin followed by sub-therapeutic doses of chemotherapy or other medications well below their proven efficacy. Theoretically, IPT boosts the pharmacologic efficacy of medications by increasing uptake into the cells of the body. During IPT enough insulin is given to induce hypoglycemic shock (perspiratio...